Studies on Phenanthrene Derivatives. VII

Studies on Pure Red Cell Aplasia . VII .

An 1 8-yr-old female with chronic active The patient’s plasma was cytotoxic for hepatitis developed a severe anemia due erythroblasts. Following splenectomy, a to a lack of red cell production. Her bane remission of the disease occurred. This marrow showed many large proerythrostudy indicates that in some cases the blasts but an almost complete lack of more anemia associated with abundant marro...

Studies on nicotinamide derivatives.

Lipophilicity Studies on Thiosemicarbazide Derivatives.

The lipophilicity of two series of thiosemicarbazide derivatives was assessed by the RP-HPLC method with the RP-18 chromatographic column and the methanol-water mixture as the mobile phase. Distribution coefficients logPHPLC were compared to calculated values generated by commonly used AClogP software and quantum chemical calculations. The reliability of the predictions was evaluated using the ...

Some Biochemical and Electrophoretic Studies on Purified Prothrombin , Factor VII (

S TUDIES of the chemical nature of prothrombin have indicated a glycoprotein structure.2 Data obtained on purified bovine prothrombin have shown the reducing sugar content to be approximately 5 per cent, based on a reference standard of galactose and mannose.35 Laki et al.5 reported a value of 6.5 per cent in terms of glucose, and 1.6 to 1.7 per cent hexosamine. Alexander6 and colleagues observ...

Molecular docking studies on xanthohumol derivatives as novel ‎anticancer agents ‎

A set of Xanthohumol derivatives were selected and molecular docking studies of these ‎compounds on thioredoxin reductase were conducted. Based on new structural patterns using in ‎silico-screening study, new potent lead compounds were designed. The results due to validated ‎docking protocols lead to find that Thr58, Gly57, Gly21, Asp334, Glu163, Ala130, IIe332, ‎Val44 and Gly132 are the main a...